Sustainable Seattle, a non-profit organization founded in that promotes urban sustainability, had brought together a number of organizations for the event, and thankfully there were other sustainability 'newbies' like me at the workshop: Small and medium-sized business owners; employees who are getting their triple bottom line reporting effort off the ground; consultants, students and volunteers who are learning about or managing the economic, environmental and social impacts of business. According to the workshop description, the event was intended to help participants:
In the setting of DNA damage, BRCA1 in part functions in cell cycle arrest allowing repair, which would confer resistance to these agents because the cell would be able to repair the damage that the drug had caused. If BRCA1 function is lost, the DNA damage checkpoint is lost, the cell does not have an opportunity to repair itself, and it is killed by such chemotherapy.
Therefore, DNA-damaging agents may be particularly toxic to these cells [ 14 ]. Challenges in the Clinical Setting Although there may be a connection between BRCA and triple-negative disease, there have been challenges in moving from preclinical research to clinical practice.
One retrospective analysis evaluated neoadjuvant therapy in patients with BRCA1 germ-line mutations treated with a variety of neoadjuvant chemotherapy combinations, including a prospective trial of a few patients treated with cisplatin alone.
Although this retrospective study had certain baseline confounding issues, it suggests particular sensitivity to cisplatin among BRCA1 mutation carriers [ 16 ]. Therefore, it still remains to be seen whether BRCA status can be used as a surrogate for response in triple-negative patients.
PARP inhibition involves synthetic lethality, meaning cell death by targeting more than one pathway, when impairment of one pathway alone is not lethal Fig.
In a normal cell receiving certain types of DNA damage, several opportunities exist to repair that damage, including homologous recombination, which is BRCA1-dependent, or base excision repair BERhighlighted because it is a PARP-dependent function.
Essentially, synthetic lethality means that if one mechanism is lost, the cell remains viable; however, if both routes are lost, the cell loses both primary and alternate methods for DNA repair, and dies.Introduction to The Platinum Rule ® Behavioral Style Assessment "Do Unto Others as THEY Would Have You Do Unto THEM" Dear Sample,.
Congratulations on completing the Platinum Rule ® Behavioral Style Assessment. Using your personalized and comprehensive assessment will help you become a better, more productive and successful you. The triple constraint is about balancing each constraint to reach a successful conclusion. As the project progresses, the project manager may find that any changes impact one or more of the constraints.
Platinum Metals Rev., , 30, (2), The previously noted advantages of membrane catalysts may be combined by performing the hydrogen evolution reaction on one side of the catalyst and the hydrogen addition reaction on the other side The hydrogenation reactions of triple C≡C bonds into double C=C bonds.
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Photo - DJs - Video -. The term “Triple Bottom Line” dates back to the mid ’s, when management think- tank AccountAbility coined and began using the term in its work.
3 The term found public currency with the publication of the British edition of John Elkington’s Cannibals. We need a Triple Aim for Health Equity Triple Aim (the goals of which are to improve the patient experi-ence, reduce per capita costs and improve the health of populations)3 has prompted mortality and benefits adults and employ-ers by increasing the use of preventive.